Also Included In: Arthritis / Rheumatology; Immune System / Vaccines
Article Date: 16 Oct 2012 - 3:00 PDT
Current ratings for:
Novel Potential Treatment For Autoimmune Diseases Inspired By Mother Nature
| Patient / Public: |  |
|
| Healthcare Prof: | | 5 (1 votes) |
| Article opinions: | 1 posts |
Reproducing a rare type of B cell in the laboratory and infusing it back into the body may provide an effective treatment for severe autoimmune diseases such as multiple sclerosis or rheumatoid arthritis, according to researchers at Duke University Medical Center.
The findings, which were demonstrated in mice, highlight the unique properties of a subset of B cells that normally controls immune responses and limits autoimmunity, in which an organism mistakenly attacks its own healthy tissue. The work appears Oct. 14, 2012, in the journal Nature.
B cells are the component of the immune system that creates antibodies, which fight pathogens like bacteria and viruses. However, a small subset of B cells, called regulatory B cells, works to suppress immune responses. These B cells are characterized by a cell-signaling protein called interleukin-10 (IL-10), giving these regulatory B cells the name B10 cells.
While B10 cells are small in number, they are important for controlling inflammation and autoimmunity. B10 cells can also limit normal immune responses during infections, reducing inadvertent damage to healthy body tissue.
"Regulatory B cells are a fairly new finding that we're just beginning to understand," said Thomas F. Tedder, PhD, professor of immunology at Duke and study author. "B10 cells are important because they make sure an immune response doesn't get carried away, resulting in autoimmunity or pathology. This study shows for the first time that there is a highly controlled process that determines when and where these cells produce IL-10."
Tedder and his colleagues studied the process of IL-10 production in the B10 cells of mice. Creating IL-10 requires physical interactions between B10 cells and T cells, which play a role in turning on the immune system.
The researchers found that B10 cells only respond to very specific antigens. Recognizing these antigens drives the function of B10 cells, causing them to turn off certain T cells when they bind the same antigen to prevent them from harming healthy tissue.
With this understanding of B10 cells, researchers set out to learn whether B10 cells could be harnessed as a cellular therapy, given their ability to regulate immune responses and autoimmunity.
"Since B10 cells are extremely rare, it was important that we find a feasible solution to reproduce these cells outside the body to make them available," Tedder said.
The researchers learned that the B10 cells could be isolated from the body and would maintain their ability to regulate immune responses. Moreover, they could be reproduced in large numbers.
"Normal B cells usually die quickly when cultured, but we have learned how to expand their numbers by about 25,000-fold. However, the rare B10 cells in the cultures expand their numbers by four-million-fold, which is remarkable. Now, we can take the B10 cells from one mouse and increase them in culture over nine days to where we can effectively treat 8,000 mice with autoimmune disease," said Tedder.
When a small amount of B10 cells were introduced into mice with multiple sclerosis-like autoimmune disease, their symptoms were significantly reduced, essentially turning off the disease.
"B10 cells will only shut off what they are programmed to shut off. If you have rheumatoid arthritis, you would want cells that would only go after your rheumatoid arthritis," continued Tedder. "This research shows that we may have the potential to unharness regulatory cells, make millions of copies, and introduce them back into someone with autoimmune disease to shut down the disease. This may also treat transplanted organ rejection."
Additional research is needed to learn how to expand human B10 cells and determine how B10 cells behave in humans, building on the study's insights into the mechanisms behind their function and autoimmunity.
"Autoimmune diseases are very complicated, so creating a single therapy that allows us to go after multiple disease targets without causing immunosuppression has proven to be difficult." Tedder said. "Here, we're hoping to take what Mother Nature has already created, improve on it by expanding the cells outside of the body, and then put them back in to let Mother Nature go back to work."
Visit our multiple sclerosis section for the latest news on this subject.
The research was supported by grants from the National Institutes of Health (AI56363 and AI057157), the Lymphoma Research Foundation, and the Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH.
Duke University Medical Center
MLA
n.p. "Novel Potential Treatment For Autoimmune Diseases Inspired By Mother Nature." Medical News Today. MediLexicon, Intl., 16 Oct. 2012. Web.
22 Oct. 2012. <http://www.medicalnewstoday.com/releases/251526.php>
APA
http://www.medicalnewstoday.com/releases/251526.php.
Please note: If no author information is provided, the source is cited instead.
Visitor Opinions (latest shown first)
appreciation - Novel Potential Treatment For Autoimmune Diseases Inspired By Mother Nature
posted by mashinini jabulile on 17 Oct 2012 at 9:52 ami realy want to say thanx for this research. im a student at the vaal university of technology in south africa nd i came across this article. it realy is gona come to cure the autoimmune disorders. may you kindly send me the full article. i would like to use this to the assignment im requested to do.
Add Your Opinion On This Article
'Novel Potential Treatment For Autoimmune Diseases Inspired By Mother Nature'Please note that we publish your name, but we do not publish your email address. It is only used to let you know when your message is published. We do not use it for any other purpose. Please see our privacy policy for more information.
If you write about specific medications or operations, please do not name health care professionals by name.
All opinions are moderated before being included (to stop spam)
Contact Our News Editors
For any corrections of factual information, or to contact the editors please use our feedback form.
Please send any medical news or health news press releases to:
Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.
No comments:
Post a Comment